Staffing services voor de Life Sciences industrie

Scientist Biophysics in Leiden fulltime

Research & Development / Lab Leiden 40 uur Detachering #1263

De organisatie

Janssen Vaccines and Prevention BV, one of the Janssen Pharmaceutical Companies of Johnson & Johnson, is dedicated to bringing meaningful innovation to global health. The teams focus on discovering, developing, manufacturing, and marketing vaccines to protect people worldwide from infectious diseases.


The Bacterial Vaccines (BacVac) department is working on the discovery and early development of novel vaccines for bacterial infectious diseases. It strives to address unmet medical needs, such as bacteremia (sepsis), meningitis, respiratory tract, and nosocomial infections. The projects at the Bacterial Vaccines department are primarily structured on scientific and technical collaboration with external biotechnology partners (governmental and industrial) that are innovative leaders in their field. This working process includes ‘state of the art’ vaccine discovery, with subsequent in vivo evaluation of these vaccine candidates in animal models for immunogenicity and/or efficacy. Besides, manufacturing processes are optimized and established, and the resulting clinical trial material is evaluated in human clinical studies.

The Bacterial Vaccines department has well-equipped laboratories and the possibility to acquire additional equipment and laboratory space. In addition, Janssen’s support departments, such as Vaccine Process & Analytical Development (VPAD) and Quality Control (QC), provide expertise to the Bacterial Vaccines department and its external partners to develop our prototype vaccines.

De functie

What’s in it for you?

The Biophysical Testing Unit (BTU) is part of the BacVac analytical development team. BTU is responsible for:

  • Leading analytical investigations for the research-grade drug substances, drug products, and reference antigens
  • Analyzing the quality of drug substances produced by the BacVac process team or CROs
  • Overseeing the contract analytical research work performed by collaborators (CROs & academic partners)
  • Development and implementation of new and innovative Analytical Technology Platforms
  • Subject matter experts in:

o Biophysical characterization of antigens
o Stability study of the drug substances and their blended mixtures
o Characterization of adjuvant systems
o Biophysical characterization of large molecules (Nano DSF, Auto DSC, CD, DLS & SEC-MALS)
o Discovery stage platform formulation development

Het profiel

Requirements for the function as Scientist Biophysics:

Education: Ph.D. or M.Sc. with equivalent experience


  • Experience with formulating large molecules (recombinant proteins, glycoproteins, glycopeptides, polysaccharides), proteins, and glycoconjugates.
  • Experience in large molecule characterization
  • Experience in characterization of particulate adjuvant systems

Specific knowledge:

  • Knowledge of analytical literature, with emphasis on biophysical characterization of large molecules.
  • Excellent understanding of the formulation of large molecules.
  • Knowledge of planning stability studies for large molecules.

Must have experience:

  • HPLC (SEC, RP, NP, etc.)
  • An advanced knowledge on anyone of the technique is a plus -Nano DSF, Auto DSC, CD, DLS & SEC-MALS)
  • Nice to have: C SDS-PAGE, cIEF, cWES, and molecular modeling of proteins and ligands

Extra requirements:

  • A valid working permit until January 2023 is required.
  • You are available on a short notice (latest Feb 1st 2022).

Het aanbod

This is a 40 hrs/week contracting role through Herakles for initially twelve months. Extension of the assignment may be possible.
Salary depending of experience and education. Maximum €60.000,- gross/year.

Inlichtingen bij

Interested in this role as a Scientist Biophysics? Please apply via the button. If you have any questions please reach out the recruiter mentioned below.

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Meer informatie over deze vacature

Lisette Spoelder

Associate Director Recruitment & Accountmanagement